Formulation of Self Micro-Emulsifying Dry Powder of Zingiber officinale (Rhizome) and Its Effect on Hepatoprotective Activity in Mice Model

Liver complication is a major concern in the world. Finding out new way to combat various liver diseases very much required. Ginger has been reported have hepato-protective activity. Here we aimed formulate an oil-based (self-micro emulsifying) powder improve hepatoprotective activity of dry Zingiber officinale (Ginger). Four different formulations self-microemulsifying were prepared by mixing with excipients. The formulated was characterized for angle repose, Hausner ratio and compressibility index. evaluated vivo. All parameters tested characterization showed good response terms flow property compressibility. Formulated exhibited significant decrease (p<0.05) hepatic enzymes like aspartate transaminase (AST) alanine (ALT) carbon tetrachloride (CCl4) induced hepatotoxic mice compared fresh ginger group which indicates enhanced self-micro emulsifying power hepatotoxicity. Bangladesh Pharmaceutical Journal 26(2): 125-133, 2023 (July)